Gene
insl5b
- ID
- ZDB-GENE-070122-5
- Name
- insulin-like 5b
- Symbol
- insl5b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled receptor binding activity. Predicted to be located in extracellular region. Is expressed in several structures, including enteroendocrine cell; female organism; gonad; gut; and male organism. Orthologous to human INSL5 (insulin like 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Insulin-like | Insulin-like_neuropeptide_ligands | Insulin-like superfamily |
|---|---|---|---|---|---|
| UniProtKB:A0ZYT5 | InterPro | 100 | |||
| UniProtKB:A0AB32TVJ9 | InterPro | 111 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
insl5b-201
(1)
|
Ensembl | 374 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-252G14 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195262 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195283 | ZFIN Curated Data |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001128556 (1) | 374 nt | ||
| Genomic | GenBank:CU104710 (1) | 93492 nt | ||
| Polypeptide | UniProtKB:A0AB32TVJ9 (1) | 111 aa |
- Alnafea, H., Vahkal, B., Zelmer, C.K., Yegorov, S., Bogerd, J., Good, S.V. (2019) Japanese medaka as a model for studying the relaxin family genes involved in neuroendocrine regulation: Insights from the expression of fish-specific rln3 and insl5 and rxfp3/4-type receptor paralogues. Molecular and Cellular Endocrinology. 487:2-11
- Venditti, M., Donizetti, A., Fiengo, M., Fasano, C., Santillo, A., Aniello, F., Minucci, S. (2018) Temporal and spatial expression of insulin-like peptide (insl5a and insl5b) paralog genes during the embryogenesis of Danio rerio. Journal of experimental zoology. Part B, Molecular and developmental evolution. 330(1):33-40
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Good, S., Yegorov, S., Martijn, J., Franck, J., and Bogerd, J. (2012) New insights into ligand-receptor pairing and coevolution of relaxin family peptides and their receptors in teleosts. International Journal of Evolutionary Biology. 2012:310278
- Good-Avila, S.V., Yegorov, S., Harron, S., Bogerd, J., Glen, P., Ozon, J., and Wilson, B.C. (2009) Relaxin gene family in teleosts: phylogeny, syntenic mapping, selective constraint, and expression analysis. BMC Evolutionary Biology. 9:293
- Yegorov, S., Good-Avila, S.V., Parry, L., and Wilson, B.C. (2009) Relaxin family genes in humans and teleosts. Annals of the New York Academy of Sciences. 1160:42-44
- Donizetti, A., Grossi, M., Pariante, P., D'Aniello, E., Izzo, G., Minucci, S., and Aniello, F. (2008) Two neuron clusters in the stem of postembryonic zebrafish brain specifically express relaxin-3 gene: First evidence of nucleus incertus in fish. Developmental Dynamics : an official publication of the American Association of Anatomists. 237(12):3864-3869
- Park, J.I., Semyonov, J., Chang, C.L., Yi, W., Warren, W., and Hsu, S.Y. (2008) Origin of INSL3-mediated testicular descent in therian mammals. Genome research. 18(6):974-985
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
1 - 9 of 9
Show